Postpartum Care

Here’s the RoshReview Question of the Week:

A 23-year-old G1P1001 woman presents to the office for her routine postpartum visit. She is 6 weeks postpartum status post vaginal delivery of a healthy infant. Her pregnancy was complicated by diet-controlled gestational diabetes mellitus and obesity. She completes a 2-hour glucose tolerance test using a 75 g glucose load. Her fasting plasma glucose level is 85 mg/dL, and her 2-hour plasma glucose level is 130 mg/dL. Which of the following is the most likely diagnosis?


More Reading: ACOG Committee Opinion 736 from May 2018: Optimizing Postpartum Care 

Why Do We Care About PP Care? 

  • The days/weeks following birth are critical for patient and infant well-being 

    • Multiple physical, social, and psychological changes 

    • Recovery from delivery (either vaginal or cesarean) 

    • Challenges of breastfeeding

    • Lack of sleep, fatigue, pain, stress

    • New or exacerbation to mental health disorders 

    • Urinary or even anal incontinence 

  • Challenges 

    • Fragmented care between pediatric and obstetric care providers: 

      • As an example of what babies get: day 1-2 of life, day 3-5 of life, 1 month check up, 2 month, 4 month, 6 month, 9 month, and 12 month 

      • Just for well babies! 

      • If other complications, maybe more visits! 

    • Long time before we see our patients 

      • Usually, will see them at 4-6 weeks postpartum 

      • Initial lack of attention to maternal health needs - more than half of pregnancy related deaths occur after the birth of the infant! 

      • Instead of ongoing care, we have fragmented, one or two time visits 

A Call to Action 

  • Because of these issues, ACOG has wanted to increase awareness for the fourth trimester 

  • What we currently have - (FYI, this is me ranting about our current system because I’m a raging socialist. Feel free to chop as much as needed) 

    • 4-6 week visit x1 

    • Edinburgh postpartum depression screens to try and catch postpartum blues, but administered in the hospital and again at 4-6 weeks - can miss depression in the first month after birth

    • With COVID, often not letting family members or infants come to postpartum visits 

    • All pregnant patients receive health insurance through Medicaid, but this insurance stops at 6 weeks postpartum 

    • The US is also one of 7 countries in the entire world without paid maternity leave (WTF) 

    • On average, countries that provide paid maternity leave pay 77% of previous pay 

    • The UK has paid maternity leave minimum of 39 weeks. Most places have a minimum paid maternity leave of 12 weeks to a full year, and on average, globally, the paid maternity leave is 29 weeks. Average paternity leave is 16 weeks 

NY Times

  • What this results in

    • Less attendance of postpartum visits

      • Not wanting to use accrued family leave/sick days for appointments 

      • Unable to find someone to care for themselves/their infants to go to appointments 

      • Results in as many as 40% of patients don’t go to postpartum visits 

      • 23% of employed women return to work within 10 days postpartum, and an additional 22% return to work between 10-40 days pp!!!!! 

    • Less anticipatory guidance

      • With decreased time during pregnancy (due to covid) and also with not going to postpartum visits and not having PP visits soon enough → on a national survey, less than ½ of patients attending a PPV reported the received enough info about depression, birth spacing, healthy eating, importance of exercise, changes to their sexual response and emotions 

      • In randomized controlled trial, 15 minutes of anticipatory guidance before discharge, followed by phone call at 2 weeks reduced symptoms of depression and increased breastfeeding duration through 6 months among black and hispanic women  

    • More maternal morbidity and mortality 

  • What we want (and ACOG wants) 

    • Timing of postpartum visit be individualized and woman centered 

    • Initial assessment within 3 weeks postpartum to address acute issues 

    • Follow this up with ongoing care as needed - ie. well woman visit no later than 12 weeks after birth 

    • Insurance should allow for this care (don’t take it away after 6 weeks!)

      • American Rescue Plan Act - allows states to extend Medicaid coverage for pregnant people from 60 days to 1 year postpartum 

      • As of 4/2022: currently in effect for 13 states 

      • 14 states and DC planning to implement a 12 month extension 

      • 4 states with limited overage extension approved or proposed 

      • 4 states pending legislation to seek federal approval 

What should we be doing then for PP Care? 

  • Start early - begin anticipatory guidance even in prenatal care! 

    • Develop a postpartum care plan (Table 1 - can go through some of these things) 

    • Reproductive life planning 

      • Review desire for future pregnancies 

      • Counsel pregnancy spacing (avoid short interval pregnancy, within 6 months, and risks and benefits of pregnancy sooner than 18 months) 

      • Review contraception options if desired 

    • Build a support system 

      • Review: who will provide social and material support? Ie. family, friends

        • Can get social work involved if needed  

      • Identify providers that patient can call with questions

        • Primary care provider, Ob provider, psychiatry provider 

        • Pediatric provider 

        • Lactation support 

        • Care coordinator/case manager 

        • Home visitation 

        • Provide phone numbers or other contact information  

  • Intrapartum to Postpartum Care

    1. Early postpartum period contains substantial morbidity 

    2. Blood pressure evaluation no later than 7-10 days postpartum for those with hypertension

      1. Great studies regarding postpartum blood pressure checks via text message - easy for both patients and clinicians

      2. Decreases usage of emergency rooms 

      3. Those with severe hypertension should be seen within 72 hours!  

    3.  In person follow up earlier for patients with complications such as: 

      1. Cesarean section or perineal wound infection 

      2. Lactation difficulties 

      3. Chronic conditions like seizures that may require postpartum medication titration 

    4. WHO recommends follow up of all women and infant dyads at 3 days, 1-2 weeks, and 6 weeks - we don’t do this in the US! 

    5. Based off of this ACOG recommends first contact within 3 weeks (does not have to be in person, can be by phone) 

    6. Can set up postpartum care either in the prenatal period (we will usually make pp appointments for patients in the hospital or right before delivery) 

  • The components of postpartum care - these were really good from ACOG, so thought I would include 

    1. Mood and emotional well-being 

    2. Infant care

    3. Sexuality, contraception, birth spacing 

    4. Sleep/fatigue 

    5. Physical recovery 

    6. Chronic disease management 

    7. Health maintenance 

What about birth trauma? 

  • Remember that trauma is in the eye of the beholder

    • Many healthcare providers may not even be aware that their patient experienced trauma 

    • Allow patients to ask questions about their labor, childbirth course and review any complications 

    • Complications should be reviewed and how they can best be avoided in next pregnancy if possible (ie. reduce risk of preterm birth, preeclampsia)  

    • Referral to support group, mental health care specialist 

  • Pregnancy loss 

    • Remember to always review someone’s labor course and delivery!

      • May sound basic, but there are times when people miss a cesarean scar or even that someone had a pregnancy loss and congratulate the patient (omg)  

    • Emotional support and bereavement counseling with referrals if appropriate 

    • Review labs and path from loss 

    • Order other labs if needed (look at our stillbirth episode) 

Transition to ongoing care 

  • Refer to ongoing well woman care within 12 weeks 

  • Make sure that there is a good transition for birth control/continued prescriptions

    • Write this out in your notes/recommendations 

    • Many patients all of a sudden don’t have access to get their birth control because their obstetrician or midwife isn’t seeing them anymore 

    • Or, if their OB started them on an antidepressant, all of a sudden, they don’t get scripts anymore because they are not longer postpartum - make sure to help patients get appointments to their PCP or mental health care and transition them!  

Special Episode: Abortion Rights in the USA

In light of this week’s events, Fei and Nick sit down to talk through abortion rights in the US and evaluate the place of abortion as healthcare in the US.

The Current State of Abortion in the USA

  • Earlier this week: leaked Supreme Court document to overturn Roe v. Wade 

    • If you have not: https://www.politico.com/news/2022/05/02/supreme-court-abortion-draft-opinion-00029473

    • Just so we are clear, this does not mean that Roe V. Wade is overturned 

      • Per Politico: “Deliberations on controversial cases have in the past been fluid. Justices can and sometimes do change their votes as draft opinions circulate and major decisions can be subject to multiple drafts and vote-trading, sometimes until just days before a decision is unveiled. The court’s holding will not be final until it is published, likely in the next two months.” 

  • Roe V Wade has not yet been overturned, so in the US, technically abortion is still legal 

Where Things Stand if Roe is Overturned

  • There are multiple states that have restrictions in some way or other. So for example, only 6 states have no restrictions on abortion: 

    • Oregon, Colorado, New Mexico, New Jersey, Vermont and New Hampshire 

    • Most states have limitations at viability, and certain states have limitations at 24-25 weeks

      • 24-25 week limitation: Nevada, PA, FL, Massachusetts, and Virginia 

      • Still others state “viability” but individual institutions limit the gestational ages, effectively making the limitation less than viability (AHEM RI, Women and Infants ← don’t have to actually call them out)  

    •  Some states have 22 week limits (North Dakota, South Dakota, Nebraska, Kansas, Oklahoma, Iowa, Wisconsin, Indiana, Ohio, West Virginia, Georgia, South Carolina, Alabama, Louisiana, Arkansas 

    • Others have limitation at 15 or 20 weeks (Mississipi, Kentucky) 

    • Most restrictive: Texas, at 6 weeks 

  • And still more restrictions exist beyond gestational age:

    • In the setting of minors, parental consent or inform laws exist for all but 7 states 

    • There is also a mandatory waiting period for 24 hours or more in 24 states 

    • State constitutional protection of abortion exist in only 14 states 

    • No government funding for abortion (US government insurance will not fund it) 

      • First trimester abortions can cost $500-$1000 out of pocket 

  • Currently, should Roe v. Wade get overturned, legislatures in 22 states said they would move to ban or further restrict abortion laws 

US Case Law Regarding Abortion Rights

  • Roe V. Wade (1973)

    • Court case involving Norma McCorvey (Jane Roe) who became pregnant in 1969 with her third child 

    • She could not have an abortion as she wanted because in Texas it was illegal 

    • Her attorneys filed a lawsuit on her behalf in the US federal court, alleging that the Texas abortion laws were unconstitutional

    • The US District Court ruled in her favor and the state appealed to the Supreme Court 

    • In 1973, the Supreme Court Ruled in a 7-2 decision that per the Due Process Clause of the Fourteenth Amendment, this provides a “right to privacy” that protects a woman’s right to choose 

    • However, there were clauses: 

      • Right is not absolute and must be balanced against governments’ interests in protecting women’s health and prenatal life 

      • Tied state regulation to the three trimesters of pregnancy: during first trimester, government could not prohibit abortion at all; second trimester, government could require reasonable health regulations; during third trimester, abortion could be prohibited entirely so long as the laws contained exceptions for cases when they were necessary to save the life or health of the mother 

    • What this means: yes, abortion was now legal, but it left a lot up for interpretation 

      • States could still enact other provisions that would make it difficult to get an abortion (ie. long waiting periods, informed consent laws, spousal or parental consent) 

  • Planned Parenthood vs. Casey (1992) 

    • Another landmark trial where the Court upheld the right to have an abortion that was established in Roe v. Wade 

    • The case arose from a challenge to 5 provisions of the Pennsylvania Abortion Control Act of 1982

      • The provisions included (not limited to) requirements for waiting period unless there was a “medical emergency,” spousal notice, and parental consent for minors (other two were informed consent and reporting requirements or record keeping for abortion service facilities) 

    • The court upheld Roe and also overturned the original trimester framework in favor a viability analysis  

      • While this is typically seen at 24 weeks, but since Casey, states have enacted laws to restrict abortion, including abortions earlier than the general standard of 24 weeks 

      • Also replaced the strict scrutiny standard of review required by Roe with the “undue burden” standard, under which abortion restrictions would be unconstitutional when they were enacted for “the purpose or effect of placing a substancial obstacle in the path of a woman seeking an abortion of a nonviable fetus” 

      • The court upheld 4 provisions of the PA law, but invalidated the requirement of the spousal notification 

  • Dobbs v. Jackson Women’s Health Organization (2022)

    • Pending US supreme court case dealing with the constitutionality of the 2018 Mississippi state law that bans abortions after 15 weeks 

    • In March 2018, Mississippi passed the Gestational Age Act 

    • Within a day, the remaining abortion clinic in MS (Jackson Women’s Health Organization) sued the state challenging the constitutionality of the bill 

    • In the district court for southern MS, the judge ruled for the clinic and placed an injunction on the state enjoining them from enforcing the Act 

    • State appealed to the Fifth Circuit → upheld the judge’s ruling

    • The state then petitioned their act to the Supreme Court in June 2020 - case was heard on December 2021

    • Which then leads us to our leaked Politico draft that appears to overturn Roe v. Wade on May 2, 2022! 

What about other countries / guidelines?

  • WHO guidelines - recently updated on 3/9/2022: https://srhr.org/abortioncare/

    • It’s very long, but some important points as below: 

      • WHO recommends against mandatory waiting periods

      • Recommend that abortion be available on request of the woman/pregnant person without authorization of any other individual, body, or institution 

      • Recommend against laws and other regulations that prohibit abortion based on gestational age limits 

      • Recommend the full decriminalization of abortion

      • Recommend against the use of ultrasound scanning as a prerequisite for providing abortion services 

  • Other countries

    • Canada - no laws or restrictions regulating abortion

    • In most countries (other than the US and Australia) - right to abortion has been legalized by respective parliament/government instead of by state 

    • Legal in all European nations, though some gestational age limits apply 

      • Usually up to 16 weeks

Why is abortion healthcare? 

  • Abortion History in the US 

    •  1973 - Roe V. Wade; abortion is a constitutional right 

      • Three years later: Hyde Amendment; block federal funds from being used to pay for abortion outside of narrow scope of rape, incest, or life endangerment 

    • Prior to this: 

      • Until the early 1800s, abortion was legal until “quickening” 

      • Shift toward banning abortion was born from racism, misogyny, and desire to control pregnant people’s bodies

        • In mid 1800s: US shifted toward criminalizing abortion 

        • Black midwives and healers were condemned for performing abortions and care of pregnant people 

        • Motivated potentially by declining birthrates of white Protestant American women in the 1800s and increased migration 

Safe Abortion Care and Why It is Needed

  • It will occur whether or not it is prohibited

    • The Guttmacher Institute reports that in 2017 the abortion rate in countries that prohibit or limit abortion was 37/1000 people and the abortion rate was 34/1000 people in countries that broadly allow for abortion 

    • Unsafe abortion leads to 4.7-13.2% of maternal deaths  

  • Most abortions occur early on and is safe when there is good healthcare

    • According to the CDC, in 2016, 65.5% of abortions occurred at 8 weeks or less 

    • 91% occured before 13 weeks  

    • Only 1.2% of abortions are performed at 21 weeks or later 

  • For ways that abortions are done: look at our previous abortion episodes

  • Abortions are safer than pregnancy

    • Risk of death from abortion is <1/100,000; risk of dying in childbirth is 14xgreater than risk of dying from an early abortion 

    • Complications from medication abortion is <1% of patients 

    • Rate of complication in surgical abortion is 0.5-4% 

    • It does not increase your risk of future cancer and does not decrease your fertility

  • Who gets abortions?

    • Guttmacher Institute in 2014: 

      • 39% white, 28% black, 25% LatinX 6% Asian/PI, 3% other  

      • So the demographic is everyone 

    •  In addition:

      • 62% identified as religiously affiliated

      • 59% were people that had children 

      • 60% were people in their 20s  

    • Reasons for abortions

      • 74% state that having a child would interfere with education, work, or ability to care for dependents (so abortions decrease the risk that someone becomes unable to work, relies on the state for welfare – this is what conservatives want right??  ← don’t have to say this … it’s just my rage) 

      • 73% could not afford a baby (again, that person is being fiscally smart!) 

  • It is hard to get access to abortion care already, even in “liberal” states 

    • Among women seeking care for abortion in California, 11.9% traveled 50 miles or more 

    • Especially those who seek second trimester abortions or who live in rural areas 

    • One study of 6022 telemed requests: 76% of requests were from states with hostile restrictions

      • However, 60% reported a combination of barriers to clinic access and preference for self-management for privacy and convenience 

    • Why is this important to know? 

      • There are inevitably those that cannot travel 50 miles or more (and this is Cailfornia!) 

      • There are those who do not have $500-$1000 lying around for abortion 

      • What this means is that right now, safe, legal abortion is effectively unattainable for those people who are poor or do not have resources 

      • By further restricting abortion laws, we are going to inevitably make things worse for those who do not have resources (people with money and resources will always be able to get abortions) 

Call to Action: Based off the ACOG CO 815 Increasing Access to Abortion

  • The Hyde amendment and any law that restrict public or private insurance coverage of abortion should be eliminated 

  • There should not be undue barriers that restrict access to abortion including but not limited to: 

    • Bans by gestational age 

    • Requirements that only a physician or an Ob/Gyn give abortion care 

    • Telemedicine bans 

    • Restrictions on medication abortions (including mailing medication through the USPS) 

    • Requirement for mandatory counseling

    • Waiting periods before abortion 

    • Ultrasound requirements 

    • Mandatory parental consent/informing of parents 

    • Mandatory spousal consent or informing of spouse 

    • Faciliy and staffing requirements as outlined in the Targeted REgulations of Abortion Providers (TRAP) laws 

  • Ob/Gyn and family medicine practices will have opt-out abortion training for medical student, resident, and advanced-practice clinicians, and government funding will be ensured for these programs 

  • Obtaining an abortion or aiding another to obtain an abortion, or providing an abortion should not be considered criminal activities

  • Institutions should see abortion as healthcare and support it as such 

  • Any decision for abortion and method of abortion should be between the patient and her healthcare provider, and not be dictated by the government, healthcare facility, or ability to pay for abortion  

What can you do to help?

  • VOTE! 

  • Talk to your institutions – see if they will make a commitment to keeping abortion care as part of their practice 

  • Call your representatives

    • We know that you are all from different places, but we are especially talking to folks from the United States 

    • Find your senators here: https://www.senate.gov/senators/senators-contact.htm

    • Find your representatives here: https://www.house.gov/representatives

    • Let them know you are a constituent 

    • Here is a brief script from the ACLU that you can use. Know that there are Democratic Senators that are now working on protecting abortion rights, but there is nothing written/official as of yet 

      • Hi, my name is [SAY YOUR NAME] and my zip code is [SAY YOUR ZIP CODE]. [If you’d like, you can say that you are a physician, medical student, PA, healthcare provider of any type, etc.] I’m a constituent of [SAY SENATORS’ NAME] and I’m calling to urge the senator/representative to work with others to help codify abortion rights into law. 

  • Donate or volunteer for your local Planned Parenthood

  • Donate to the ACLU and join their mailing list: 

  • Familiarize yourself further with your state (and neighboring states’) laws and regulations for abortion via the Guttmacher institute 

  • Other things 

  • As a provider 

    • If you march, make sure to protect yourselves 

      • How to protest/attend a rally/march successfully 

        • Research what others are saying about the event/rally - is it safe to go? Will there likely be counterprotesters? Could things end with violence? 

        • Try not to go alone (esp if you are female, trans, BIPOC) - it’s safer to go in a group 

        • Wear a mask

        • Bring a pack and have with you water and snacks, medications, phone, phone charger and other essentials you may need (ie. pads, tampons, bandaids) 

        • Make sure your phone is only unlockable by password (police cannot force you to unlock, but they can unlock it with your face or fingerprint against your will) 

          • Consider turning it onto airplane mode while protesting 

        • Wear comfortable, close-toed shoes 

        • Write emergency contact information or emergency legal counsel numbers on your arm in permanent marker 

        • Stay vigilant. If arrested, demand legal representation before speaking to the police 

    • If you want to be seen in your white coats, that is ok, but make sure you are safe and go in a group 

      • If you don’t want to be recognized, make sure to wear your mask/goggles, cover tattoos that are recognizable.  

    • Educate your patients and hear what they have to say 

    • Prescribe refills on birth control pills, patches, contraceptive rings, etc. 

    • Place LARCs as desired by your patients 

    • Prescribe emergency contraception and tell patients to pick them up and keep it with them 

    • Compile a list of providers/places that provide abortion services and make them readily accessible to patient if they desire them 

Disability Insurance, feat. Michael Foley

We’re back with another special Wednesday episode this week, again brought to you in part by the SMFM Thrive Initiative! SMFM Thrive is a wellness program for MFMs - but we hope that this week’s podcast will be helpful even to those outside of MFM land!

Michael Foley rejoins us today to talk about another important financial wellness topic in disability insurance!

As a reminder, Michael is a comprehensive financial advisor who runs his practice out of Scottsdale, Arizona, under North Star Resource Group. Michael was trained at Duke University and holds his Certified Financial Planner designation alongside his Certified Student Loan Professional designation. Although Michael serves a diverse group of clients with their financial and student loan needs, with two physician parents, Michael has found a specialty in working with those in the healthcare space. 

DISCLOSURE: Michael is a registered representative and investment advisor representative of Securian Financial Services. Securities and investment advisory services offered through Securian Financial Services, Inc. Member FINRA/SIPC. North Star Resource Group is independently owned and operated. 6720 N Scottsdale Rd Ste 290, Scottsdale, AZ 85253

Check out some additional resources from Michael:

Bio: https://www.northstarfinancial.com/advisors/michael-foley/

Medical Economics articles: https://www.medicaleconomics.com/authors/michael-foley-cfp-cslp?page=3

And to schedule an initial consultation with Michael click here.

Updates in Pap Screening Part II: High Grade Lesions

Here’s the RoshReview Question of the Week:

A 45-year-old woman presents to your office for follow-up. She has a history of postpartum tubal ligation. She had a colposcopy for high-grade squamous intraepithelial neoplasia. The procedure was performed at the office and revealed one white lesion after acetic acid application. Biopsy results reveal cervical intraepithelial neoplasia grade 1. The borders of this lesion were not entirely identified. Which of the following is the best next step in management?


We’re back this week with Part II on Pap smears! Let’s cover high grade lesions.

First, the easy part: any ASC-H result merits colposcopy, regardless of HPV status! The down-the-line management will vary by age. 

  • In patients aged 21-24, ASC-H and HSIL get treated the same - colposcopy.

  • In patients 25 and older, ASC-H goes to colposcopy, but HSIL can proceed immediately to excision, or perform colposcopy first prior to excision.

  • Why is there an option to go straight to excision?

    • The overall 5 year CIN2+ risk for HSIL above age 25 is 77%, and for CIN3+ its 49%. Given those high risks, it is acceptable to proceed directly to excision without colposcopy.

    • Most women with HSIL will have HPV+ testing. 

      • But even with negative HPV results, an HSIL test carries a 5-year risk of CIN3 of 25% and an invasive cancer risk of 7%. Thus, it’s still acceptable to proceed straight to excision in this scenario. 

        • One way to think about this is the number needed to treat, which is super impressive. For HSIL HPV+, the NNT is 1.7 – that is, 1.7 excisional procedures for every CIN3+ treated – a very low rate of overtreatment!

          • For HSIL HPV-, the NNT is still very low at 2.8.

So we do a colpo and get biopsies… now what?

Your biopsy result will be a histology result – so CIN1, CIN2, CIN3, AIS, or invasive cancer. Let’s review the non-invasive management strategies for post-colposcopic biopsy.

CIN1 - this depends on the preceding Pap cytology, and the patient’s age:

  • HSIL cytology: many strategies are acceptable:

    • Observation, which entails colposcopy and cytology in patients under 25, or HPV-based testing with colposcopy in patients 25 and older, at one year.

    • An excisional procedure (not recommended in patients under 25)

    • Or a pathology review to determine if there is a discrepancy in the previous interpretation of cytology or histology.  

    • With observation being most typical in younger patients:

      • Colposcopy and cytology/HPV testing should occur again in one year. 

        • If these are negative, age specific retesting should happen again in an additional year, followed by HPV-based testing every 3 years for at least 25 years.

        • If there’s any abnormality, then manage that using the ASCCP guideline for the specific abnormality; though specifically, if HSIL again, excision is recommended.

          • Unless the patient is still under age 25, then observation can be continued for up to 2 years prior to recommendation for excision. 

  • ASC-H cytology: observation is the most typical strategy:

    • Perform cytology if under 25, or HPV-based testing if > 25, in one year.

      • If negative, HPV-based testing can resume in 3 years from that.

      • If abnormal - you manage according to the ASCCP guideline.

        • Specifically, if progresses to HSIL – excision is recommended if over age 25.

        • If persistent ASC-H, can repeat again in 1 year, but excision is recommended if over age 25 and ASC-H persists for 2 years. 

        • For those under age 25, HSIL or ASC-H should persist for two years before excision is recommended.

  • Lower grade cytology (ASC-US or LSIL):

    • Repeat co-testing at 12 months and 24 months.

      • If normal, then can have repeat testing in 3 years before resuming normal age-appropriate intervals.

      • If there is an abnormality in this 2 year window, then management should be performed according to cytology – though if there’s progression to HSIL, colposcopy and/or excision is recommended using the same guidelines as we stated for ASC-H.

CIN 2 or 3 on colposcopic biopsy - this will warrant an excisional procedure, typically.

  • For CIN2, observation is considered acceptable in patients under 25, or those over 25 if there are concerns about future pregnancy that, for the patient, outweigh their concerns about cervical cancer.

    • If that’s the case, colposcopy and HPV-based testing should occur at 6 and 12 months. 

      • If two consecutive evaluations have less than ASC-H cytology and less than CIN2 histology, then testing can space to annually for 3 total years.

      • If the tests are abnormal, q6 month testing can continue for up to 2 years.

      • If CIN3 develops at any point, or the abnormalities persist for more than 2 years, excision becomes recommended.

  • For CIN3, observation is not advised – these should proceed to excision.

  • If you proceed with excision, the management is based on your excisional margins:

    • If margins are negative, then cotesting at 12 and 24 months is subsequently recommended, with repeat colposcopy needed for any abnormal result.

    • If margins are positive, then you have three choices:

      • Repeat cytology with endocervical curettage q4-6 months.

      • Repeat excision, if feasible.

      • Hysterectomy.

        • Notably, hysterectomy should only be considered if repeat excision is not feasible, or if high grade abnormalities are persistent after attempted repeat excision. 

Adenocarcinoma In Situ (AIS)

  • If AIS is identified, excision is needed to rule out invasive cancer.

    • If margins are positive, reexcision is recommended to try to achieve negative margins.

    • If margins are negative, hysterectomy is generally preferred after the excision.

      • The excision is mandatory! You can’t proceed straight to hysterectomy – because if invasive cervical cancer is advanced enough, then hysterectomy may not be the recommended treatment.

    • If margins are negative, and the patient desires fertility, then reevaluation with HPV-based testing every 6 months for 3 years, then annually for two years, is acceptable. 

      • Hysterectomy is recommended following childbearing, though! 

Other Uncommon Pap Results

Unsatisfactory Cytology

  • Super frustrating! Your Pap didn’t have enough to evaluate!

  • Recommendations:

    • Follow your HPV result if you got it!

      • If HPV positive (especially 16/18), colposcopy is warranted.

      • If HPV is negative in someone 25 years or older, or if no HPV result, or unknown HPV result, then repeat the Pap in 2-4 months.

        • If the Pap is again unsatisfactory, colposcopy is recommended – good idea to take a look and figure out what you’re missing if two in a row are not satisfactory.

Negative for Intraepithelial Lesion, but Absent transformation zone or endocervical cells

  • This is also usually an insufficient Pap that didn’t sample that transformation area from glandular to squamous cell. This is the area where most HPV-associated disease is located, so effectively this is an insufficient Pap.

    • If Age 21-24, routine screening can continue.

    • If age 25+, HPV screening can triage:

      • If negative, routine screening can continue.

      • If unknown, repeat cytology in 3 years is acceptable, or get HPV testing (preferred).

      • If positive, then you follow the HPV-positive management guideline – which as a reminder for 16/18 is colposcopy, and for other types of HPV in this case would be to repeat the HPV-based test in one year.

Atypical Glandular Cells (AGC) and Atypical Endometrial Cells (AEC)

  • For these pathologies, a number of tests are recommended:

    • If atypical glandular cells or other subcategories, 

      • Colposcopy with endocervical sampling is recommended. 

      • Endometrial sampling should also be performed if the patient is 35 or older, or under 35 with risk factors such as AUB, chronic anovulation, or obesity.

    • If atypical endometrial cells

      • Endometrial and endocervical sampling are recommended, and colposcopy can also be performed – 

        • and generally colposcopy should be performed, as if the other samplings are negative, colposcopy would then be warranted at that point. 

  • Management would then proceed on the basis of these findings.

    • If no CIN2+, AIS, or cancer, then cotesting is recommended at 1 and 2 years, and can be spaced to every 3 years after that if remains negative.

    • If CIN2+ is identified, or if the initial cytology was concerning for neoplasia, then excisional procedure is typically recommended.

Updates in Pap Screening and Management, Part I

Here’s the RoshReview Question of the Week:

A 26-year-old woman presents to the office to review her Pap smear results. Her Pap smear showed atypical squamous cells of undetermined significance with positive human papillomavirus testing. Her previous Pap results are unknown. What is the best next step in management, given this result?


We talked about Pap screening last in July 2019 and managing an abnormal Pap in January 2020.

Shortly after, the ASCCP published its updated screening and management guidelines!

And they updated their awesome Pap management app – if you have $10 to spare, you’ll definitely get value out of it in residency and likely beyond.

What’s new with Pap screening?

  • Short answer – not a lot, but there is controversy!

    • In July 2020, the American Cancer Society published new recommended screening guidelines for individuals at average risk, with three major changes:

      • Recommendation of primary HPV testing every 5 years as the screening strategy, rather than co-testing.

      • Beginning Pap screening at age 25, rather than age 21.

      • Co-testing and/or cytology are acceptable per old guidelines, but ultimately the guidelines are meant to be transitory until facility/area has accessible primary HPV testing.

    • The USPSTF guidelines overall remain unchanged (for now!), but do include the option for primary HPV testing. Highlights:

      • Screening with cytology alone starting at age 21, q3 years.

      • Co-testing acceptable at age 25, and can space with cotesting to q5 years, HPV primary screening q5 years, or cytology alone q3 years. 

      • Ending screening after benign hysterectomy with no prior high risk dysplasia, or 25+ years after high-grade dysplasia, presuming adequate negative screening previously.

    • How does ASCCP feel?

      • July 2021 Statement

      • They note that evidence does exist that primary HPV screening is safe and effective as a cancer screening strategy, and in increasingly-immunized populations appears to be more effective than cytology-based screening.

        • One referenced study noted 5-fold higher detection rates in patients with CIN2+ based on HPV screening versus cytology beginning at age 21. 

      • However, uptake has been slow and implementation has been challenging, and thus they do endorse the USPSTF guidelines that suggest greater flexibility. 

        • They offer a more qualified statement of support for the ACS  guidelines in locations that can equitably and effectively implement primary HPV screening. 

      • They also recognize that HPV self-collection may help increase access and availability to patients, and hope to identify more evidence of comparative efficacy to provider-collected specimens. 

Comparison of USPSTF 2018 and ACS 2020 screening guidelines (ASCCP statement).

Managing Abnormal Pap Smears

  • In our last episode, we gave a framework that first separated Paps into “high grade” and “low grade,” age, and HPV status. We’ll apply that again and re-review the management.

  • Ultimately, the guidelines are framed around the question of what CIN3+ risk exists:

    • The first question: is the immediate risk greater than/equal to 4%?

      • If yes → how high is that risk? 

        • If 60+%, then expedited treatment is preferred

        • If 4-24%, then colposcopy is preferred

        • If in between, either is acceptable.

      • If immediate risk of CIN3+ is less than 4%:

        • What is the risk of CIN3+ within 5 years?

          • If > 0.55%, then return in 1 year for screening.

          • If between 0.15 and 0.54%, then return in 3 years.

          • If < 0.15%, then return in 5 years.

      • “Equal management for equal risk” is the underlying principle.

  • ASCCP also adjusts risk given the clinical situation, such as a routine screen; a patient who is rarely screened; management of results during post-colposcopy surveillance; or follow ups after excision/treatment. 

ASCCP

So let’s go through possible results on Pap smears at this point. 

We’ll presume that you are either performing co-testing, or HPV-primary screening with reflex to cytology.

We’ll also presume that the patients we mention here are undergoing “routine screening” – meaning that they’ve had prior screening, or it is their first screen in their lifetime if they are under age 30. 

Finally, given the additional nuances with screening, we strongly recommend reviewing management steps using the ASCCP app for guidance.

We will just review the first steps in management plans; follow ups get very much into the weeds and are individualized – a huge plus for patients, but much more challenging for memorization!

HPV Primary Screening Management

  • HPV 16/18+ – colposcopy (and obtain reflex cytology).

  • HPV other + – reflex cytology, then follow the appropriate cytology guidelines! 

Cytology/Cotesting Guidelines

Normal Cytology

The only potential abnormal in this category for someone 25 years or older is HPV positive. The risk of CIN 2 or greater in this population is approximately 2-6%. It increases if HPV is persistently positive over time, or is type 16/18.

  • If typed and result is HPV-16 or HPV-18, colposcopy is recommended.

  • If untyped or not 16/18, repeat cotesting in 1 year.

 Low Grade Cytology (ASC-US, LSIL)

  • Age 21-24, ASC-US and LSIL get treated the same, with the recommendation for repeat cytology in 12 months. 

    • This is because the clearance of HPV-caused ASC-US and LSIL is overall high in this group, and colposcopy may lead to overly aggressive management. 

    • As long as there’s no progression to high-grade, there is no indication for colposcopy.

  • In patients aged 25-29 and 30-64, the management of LSIL and ASC-US are similar.

    • Age 30-64, ideally HPV testing is always available by cotesting or primary screening!

    • The USPSTF guidelines in 25-29 year olds though do call for cytology q3 years as the primary screening strategy.

      • LSIL or ASC-US, HPV negative: overall low risk of malignant transformation.

        • Thus, with LSIL, can repeat cotesting in 1 year.

        • With ASCUS, repeat in 3 years.

      • LSIL, HPV unknown: get colposcopy given unknown HPV status.

      • ASC-US, HPV unknown: repeat cytology in 3 years if 25-29, and 1 year if 30-64

        • Ideally both would have co-testing on the repeat evaluation!

      • LSIL or ASC-US, HPV positive: colposcopy should be performed.

      • The 5-year CIN3+ risk for both HPV+ ASCUS and LSIL are very similar, approximately 7%.

  • Finally in patients aged 65+, Pap smears are likely only continuing at this point if there have been previous abnormalities, or a lack of screening. Thus, ASC-US or LSIL with negative HPV should be treated as abnormal, and thus merit repeat cytology in 1 year. All other abnormalities (i.e., HPV positive) in this age group should receive colposcopy!

Note that we didn’t talk excisional procedures at all; low grade lesions (ASC-US, LSIL) should generally proceed to colposcopy before considering excision. 

Part II will encompass high grade lesions, so stay tuned!