Placenta Accreta Part II: Management

After last week’s initial episode, we talk through some pearls for management. Keeping it simple today:

  • Antenatal care considerations:

    • Pelvic rest, avoid travel - don’t get into a bad situation!

    • Prenatal care is fairly routine.

    • Hospitalization practices will vary by region and level of resources — i.e., admission for proximity. Bleeding should prompt admission, likely until delivery.

    • Sweet spot for delivery typically between 34-35’6 weeks, though some centers pushing towards 36+ weeks.

      • However, as Dr. Einerson mentions, the worst thing you can do is end up in an emergent delivery scenario with these patients!

    • Don’t forget about using late preterm steroids!

  • Cesarean hysterectomy tips:

    • Collins 2019 paper on evidence-based management. Don’t deliver too late!

    • Multidisciplinary / interdisciplinary care leads to less morbidity.

    • Ureteral stents: if you need them to identify ureters to safely perform surgery.

    • Some tips from our guests:

      • Approach through VML skin incision, though Maylard / Cherney incisions are also reasonable. Fundal hysterotomy (typically) to avoid messing with the placenta.

      • Decrease blood flow before addressing the bladder - they often take the uterine vessels before developing the bladder.

      • Arterial catheters such as the REBOA are to be used in experimental settings only, and are associated with serious complications.

      • If bleeding - the most experienced operators need to be there.

      • Bipolar vessel sealing devices (such as LigaSure) are helpful!

  • Conservative management?

    • To be done only on an experimental basis at this time! Reasonable to examine in a trial for a number of reasons.

    • Methotrexate does NOT work for retained placenta — MTX kills rapidly dividing cells, not stagnant cells left behind.

  • Patient resources / advocacy:

Placenta Accreta Part I - Pathophysiology, Diagnosis, and Imaging

Today we welcome two special guests to the podcast — Dr. Scott Shainker, who is an assistant professor at Beth Israel Deaconess in Boston, MA, and Dr. Brett Einerson, who is an assistant professor at the University of Utah in Salt Lake City, UT. Both Dr. Shainker and Dr. Einerson are experts in the world of placenta accreta spectrum, with numerous publications, guideline papers, and advocacy efforts to their names. We did a two part series with them on PAS. This first episode, we focus on pathology, diagnosis, and imaging. Next week, we’ll get into management and future directions.

For further reading, check out ACOG’s Obstetric Care Consensus on PAS.

PAS has traditionally been thought of as an “invasive” disease, but that thinking is evolving to think of PAS as a disease of uterine dehiscence. The loss of the uterine decidua due to prior uterine scarring (i.e., due to surgery) brings about abnormal attachment and a “superhighway of vascularity,” thus that when delivery comes, the placenta fails to separate normally. Uterine muscle dehiscence likely accounts for the degree of invasiveness. It’s likely that cesarean scar pregnancies are a precursor to PAS.

https://resident360.nejm.org/clinical-pearls/placenta-accreta-spectrum

https://resident360.nejm.org/clinical-pearls/placenta-accreta-spectrum

The PAS diagnosis and terminology is also changing, from the traditional accreta / increta / percreta divide seen above, to a FIGO staging system with both surgical and pathologic criteria. You can review those here.

We review some of the risk factors, but far and away the biggest is a combination of a prior cesarean and placenta previa. Dr. Shainker mentions Dr. Robert Silver’s landmark paper on this - the percentages are worth committing to memory. Other risk factors include other types of uterine surgery like abdominal myomectomy; IVF and ART; and potentially dilation and curettage, though that is controversial.

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Imaging is great in research capacities with high sensitivity (approaching 90+%), but only 50% of patients with accreta know about it before delivery. So the real world sensitivity is very poor. Risk factors should raise suspicion primarily, and the use of imaging help guide your preoperative suspicion. SMFM has now published a consensus on ultrasound diagnosis, which is the gold standard. More data should hopefully improve the real-world detection rates for PAS.