Pessaries for the GYN Patient, feat. Dr. Edward Kim


What are pessaries?

  • Pelvic organ prolapse (or POP) and stress urinary incontinence (or SUI) are common problems that impact millions of women in the world.

  • A pessary is a support device placed vaginally that can be used to treat symptoms of POP, SUI, or both.

    • Pessaries are generally cost effective, well-tolerated, safe and can help avoid surgery.

      • For POP, up to 90% of patients report relief of symptoms like pressure and bulge.

      • For SUI, about half of patients report improvement in urinary symptoms.

History of the pessary

  • Historically, the first use of pessary for reduction of pelvic organ prolapse was described by Hippocrates.

    • He put a halved pomegranate soaked in wine into the vagina.

  • In 1860, Dr. Hugh Lenox Hodge, an ob/gyn faculty at the University of Pennsylvania, used newly developed vulcanized rubber to create a pessary shaped more anatomically.

    • Today, most pessaries are made of soft, flexible silicone thus considered non-allergenic.

The Modern Pessary

  • The most commonly used pessaries are ring, Gellhorn and donut. 

    • Ring pessary is a go-to in practice.

      • Subtypes: Ring without support

      • Ring with support (kinda looks like a mini frisbee),
        Ring without support with a knob

      • Ring with support with a knob.

        • The knob sits under the pubic bone and helps with stress urinary incontinence. So a ring with support and a knob will address POP and SUI. Rings can be removed by patients fairly easily.

    • A Gellhorn has a stem and a concave disc (kinda looks like a baby pacifier).

      • The concave disc part sits below the vaginal apex and creates somewhat of a suction.

      • The stem sits posteriorly and prevents the pessary from flipping around.

        • Gellhorns are little more difficult to place. Patients seldom can remove them on their own.

        • For removal, a provider usually needs to grasp the stem with their fingers or a ring forceps, gently wiggle it out to break the suction allowing for removal.

        • Gellhorns are generally used for more severe prolapse.

    • A donut (as the name implies) looks like a mini donut and it achieves its function by occupying the vagina.

      • A donut works better for more severe prolapse, as well, and difficult for patients to remove on their own.

Indication and counseling:

  • Patients with symptomatic POP or SUI who desire to avoid surgery, poor candidate for surgery, desire further childbearing, current pregnancy or within 12 months postpartum.

  • Contraindications include:

    • active pelvic infection,

    • latex allergy (as some inflatable pessary are composed of latex),

    • non adherence to care and follow up

  • Studies report a very wide range of patient acceptance of pessary: from 42 to 100%.

    • Patients who decline tend to be younger, sexually active,  nulliparous, or have severe POP or SUI and desire surgical correction.

    • But it also depends on the counseling. In our practice, we discuss pessary in the range of management options for POP and SUI. We sometimes use it as a bridge between now and surgery for patients who prefer symptom relief now.

Placement:

  • Placement comes with practice and it often involves trial and error.

  • There have been no identified reliable predictors of which size pessary should be tried first.

  • Start with a ring with support pessary (ring with support and a knob if also trying to address SUI).

  • Identifying the starting size (say, 3, 4, 5) comes with practice and pelvic exam. Wet it with warm water first.

    • You could use lubricant but if you use too much it may be too slippery for you to handle and also easier for it to be expelled.

  • Fold it in half like a taco, insert, and allow it to resume its disc shape in situ. Remember, it should NOT be painful. If the patient says it’s painful once it’s placed, then it is often too big.

    • Liken it to a corrective device like glasses or contact lens. When you first start using it, you notice that it’s there. But it should not be painful and with time you often forget it’s there.

  • Then have pt Valsalva.

    • It’s okay that you can see the pessary descend as long as it does not completely get expelled.

  • Then have them ambulate and go to the toilet and Valsalva with a toilet hat to catch the pessary if it does get expelled.

    • If it’s still in situ after that and patient has no discomfort, we send them home with it.

  • Placement of Gellhorn, donuts, and other types of pessaries are little different and may be best reserved for providers who have more experience with them. But I think ring pessaries can be something everyone can have in their toolbox.

Maintenance:

  • Patients who wish to and have the dexterity to maintain the pessaries on their own are instructed to take it out and clean with warm soapy water as often as they want but usually at least once a week.

    • If they are unable to, then typically they come to the clinic every 3-4 months for maintenance.

  • Patients with Gellhorn, donut, or other types of pessaries that patients cannot remove easily on their own also follow up every 3-4 months. At these visits, the pessary is removed, gently cleaned, and a speculum exam is done to assess for any excoriation or abrasion.

  • For postmenopausal patients without contraindication for topical vaginal estrogen, we typically have them use it to prevent significant vaginal excoriation or abrasion since atrophy can worsen these.

Complications:

  • Most common complaints are increase or change in vaginal discharge or odor. Reassurance and ruling out for vaginitis and bacterial vaginosis are reasonable next steps. Reports of vaginal bleeding long after placement warrants exam in the office.

  • Spontaneous expulsion or difficulty with voiding or defecation or pain often means a different size or shape should be tried.

  • Pessaries that have been left in situ and neglected for prolonged period of time should be taken seriously. Embedded pessaries may need removal under general anesthesia.

  • But overall, it is generally very safe.

Fecal Incontinence

Here’s your RoshReview Question of the Week!

Which of the following physical exam findings would be present in a woman with fecal incontinence and disruption of the external anal sphincter?

Find out the right answer by clicking on what you think the answer is, and find out how to save 20% on a RoshReview QBank Subscription for CREOG studying!


What is Fecal Incontinence? 

  • Definition

    • Part of accidental bowel leakage - where there is loss of normal control of the bowels. The other aspect of ABL is leakage of stool and gas (anal incontinence) 

    • Fecal incontinence - specifically is leakage of stool 

    • National Health and Nutritional Examination Survey defined it as: loss of solid or liquid stool or mucus at least once in previous 30 days 

  • How common is it?

    •  NHANES survey; 8.3% prevalence (in 4308 community dwelling adults 

    • Prevalence increases with age (2.6% in 20s to 15.3% in adults 70 and older) 

    • Likely underestimated since 75-80% of individuals with fecal incontinence don’t seek help or report them to their health care provider 

  • Risk factors 

    • Loose or watery stool 

    • Increased frequency of stools (more than 21 a week) ← ok, who is pooping more than 3x a day, and how can I get to this level of regularity  

    • Having 2 or more chronic illnesses 

    • Urinary incontinence, obesity, smoking, increasing age, decreased physical activity, anal intercourse, history of OASIS, history of pelvic radiation

What are the causes of fecal incontinence? 

  • Neurologic - ie. spinal cord injuries, spina bifida, and CVAs 

  • Non-neurologic

    • Most common in women are non-neurologic, usually after OASIS, may occur even remote from delivery 

    • Medications can also cause

Why do we care? 

  • Effect on quality of life

    • Significant effect 

    • Can cause depression, social isolation, shame, embarrassment, etc 

    • Can also worsen sexual function 

How do we evaluate? 

  • Screen!

    • ACOG says women with risk factors should be screened because they are often reluctant to disclose  

    • Should ask in women with other pelvic floor disorders 

    • Other risk factors that can be considered: Age >50, residence in nursing home, prior OASIS, history of pelvic irradiation, engagement in anal intercourse, presence of urinary incontinence, chronic diarrhea, diabetes, obesity, rectal urgency 

  • History and physical 

    • Ask about underlying neurological disorders and also modifiable risk factors for fecal incontinence (ie. obesity, diabetes, smoking, anal sex, certain medications that cause loose stools) 

    • Symptoms: what type of leakage (solid, liquid, gas, mucus), timing, frequency, severity (volume of loss), if there is fecal urgency, and how this affects their life 

    • There are a few validated surveys 

      • FI Severity Index, FI Quality of Life Scale, Fecal incontinence and Constipation Assessment Questionnaire 

    • Physical exam should include vaginal exam, exam of perineal area, and rectal exam (prior anal sphincter surgery/trauma) 

      • “Dovetail” sign - loss of normal puckering around the anus anteriorly

      • Digital rectal exam - sensitivity and specificity is overall low for detection of complete anal sphincter disruption 

      • Can also consider endoanal ultrasonography 

  • Other tests

    • Anal sphincter imaging/defecography/anorectal manometry not recommended for routine evaluation 

    • However, if anatomic defect or dysfunction is suspected or if clinical exam findings are inconclusive, can refer for ancillary testing 

    • Can also consider referring to urogynecology/colorectal surgery for further evaluation if not sure in clinic 

How do we manage and treat FI? 

  • Medical

    • Should be multidisciplinary approach 

      • Consider pelvic floor PT and management with urogynecology 

      • Also can consider gastroenterology

    • Medications

      • While loose stool itself does not cause fecal incontinence, it can worsen it and be a risk factor

        • Try something to bulk up stool - ie. fiber supplementation, dietary manipulation, bowel scheduling, etc 

      • Lifestyle management - should be offered in conjunction with everything else 

        • Wearing pads, diapers, briefs, etc 

        • Anal plugs ← 51% of people reported some sort of adverse event, like urgency, irritation, pain, soreness.

    • How effective are non-surgical treatments? 

      • Associated with modest short-term efficacy and low risk of adverse events, so should be recommended for initial management unless there is a fistula or rectal prolapse on exam 

      • However, lacking evidence for effectiveness of treatment beyond 6 months 

  • Surgical

    • Anal Sphincter Bulking Agents - not really surgery, kind of in between? 

      • Include things like dextranomer in stabilized hyaluronic acid, silicon biomaterial, carbon-coated beads 

      • May be effective in decreasing FI episodes up to 6 months 

    • Who is eligible for surgeries?

      • Not first line except for the two indications mentioned above (fistula or prolapse)

      • Proven to only provide short term improvement and have more complications than medical treatments/lifestyle modifications 

      • If patients fail medical treatments → can have surgery 

      • Refer to urogynecologist or qualified specialist to do them  

    • Neuromodulation 

      • Sacral nerve stimulation is possible for ABL 

        • Implantation of wire electrode near third sacral nerve root 

        • Two step → if initial testing is beneficial, then permanent battery is attached to wire electrode 

        • 2013 systemic review: 63% success rate (50% or greater reduction of FI) in the short term (<1 year), 58% in medium term (17-36 months), 54% (44-118 months)

      • Peripheral tibial nerve stimulation is not approved for FI 

    • Anal Sphincter Repair 

      • Sphincteroplasty can be considered with anal sphincter disruption and fecal incontinence symptoms who have failed conservative treatment 

      • Can do it end to end or overlapping sphincteroplasty 

      • Most studies:

        • Found to have similar outcomes 

        • Some evidence has shown that there can be significant deterioration in fecal incontinence over time after either type of repair, with 50% of women reporting symptoms 5-10 years after their repair

      • Most common adverse effect is wound infection (6-35% of cases!!) 

    • Other surgeries can be considered:

      • Radiofrequency anal sphincter remodeling 

      • Gracilis muscle transposition 

      • Diverting colostomy  

Urinary Incontinence

On today’s episode, we visit with Dr. Kyle Wohlrab, who is an associate professor and urogynecologist at Brown University / Women and Infants Hospital of Rhode Island. He takes us through the basics of urinary incontinence.

Urinary incontinence is quite common: almost 1/3 of women in their lifetime. The Women’s Preventive Services Initiative even recommends annual standardized incontinence screening for women annually.

The mechanisms of incontinence include:
Stress - leakage with Valsalva (sneeze/laugh/cough/activity). Generally in small volumes.
Urge - aka overactive bladder; spasms or overactivity of bladder detrusor muscle that can prompt large volume leakage.
Mixed - a combination of the above; often one of the above types is “predominant.”

We review in the podcast many of the most important parts of a history and workup, but the most important aspect are the patient’s goals with respect to incontinence. This also will guide our therapy. Childbirth, obesity, and activities involving heavy weight bearing are some common risk factors.

One of the tests that can easily be performed, but many have limited experience with, is a simple cystometrogram. Essentially, one backfills the bladder. If during filling, one sees a rise in the meniscus, this is suggestive of detrusor overactivity. After filling with 200-300cc,, one can do a filled cough stress test to evaluate for stress incontinence.

Treatments vary by type of incontinence, but can be broken down into three categories for each type:
Stress - pelvic floor PT, vaginal inserts, and surgical therapy — midurethral sling, Burch urethropexy, urethral bulking.
Urge - pelvic floor PT and behavioral modification, medial therapies, and surgical therapies — neurostimulators.

For medical therapies for urge incontinence, antimuscarinic therapy is generally first line. Oxybutynin and trospium are the most commonly used medications in this class. Recall that antimuscarinic drugs have the “slow down” side effects of dry mouth/dry eyes, constipation, abdominal pain, and sedation. Newer medications in this class can have fewer side effects but can have difficulty with insurance coverage. Trospium is the newest medication that also doesn’t cross the blood-brain barrier, limiting neurologic side effects — especially useful in the elderly!

Beta agonists are another option for medical therapy with mirabegron. Rather than acting on muscarinic receptors, these act on beta agonists. These thus should be avoided in patients with uncontrolled hypertension.

When should someone refer to urogynecology? Dr. Wohlrab’s advice is to refer once someone has failed a line of therapy, or when patients begin looking for surgical therapy. Especially after listening today, we hope you’re comfortable with this workup and treatment!

Further reading from the OBG Project:
Urinary Incontinence – How to Make the Diagnosis in Your Office and When to Refer
Treating Urinary Incontinence Without Surgery: Options and Pearls
Prolapse and Stress Incontinence: Burch Procedure vs Midurethral Sling
Surgery for Urinary Incontinence – When the Sling’s the Thing